This report summarizes the analysis, normalization, and risk assessment of over 1,700 UHPLC Bill of Materials (BOM) lines, focusing on SKU consolidation, standardization across five core product families, and recommendations for reducing compliance risks and optimizing supply chain efficiency. It provides key metrics, risk trends, and actionable recommendations to enhance BOM governance and product quality.
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Executive Summary
Data Set Composition by Family
Snapshot & Strategic Context
Over 1,700 UHPLC BOM lines were normalized, grouped into five core product families. This supports global quality compliance and supply chain optimization by driving scaling, cost-out, and risk reduction opportunities.
- SKU consolidation unlocks efficiency: Only three tube lengths and standard end-fit/frits cover >95% of reference builds.
- Major field risks flagged: Cross-family or cross-diameter substitutions with mismatched torque, thread, or material are the dominant root cause of global kit failures. Attention
- Recommendation: Prioritize standardization and ensure special handling for non-stainless assemblies.
Key Metrics
Family Coverage & Standardization
BOM Lines Processed
1,710
100% Anonymized
Product Families
5
Comprehensive
SKU/Part# for SS Kits
6
Minimal Variety
Coverage of Fielded Kits
>90%
Optimal
Non-Compliance Risk Trend
Analytical Deep Dive
BOM Structure – Stainless-Steel UHPLC Kits
| Assembly | Tube | Frit | End Fitting | Torque | Washed |
|---|---|---|---|---|---|
| 2.1×50 (AX2150QZ) | RATH-2150 2.1mm × 50mm |
MVX-0021A | TARQ-21SU | 22 in-lb 2.1mm kits | Yes |
| 2.1×100 (AX2110QZ) | RATH-2110 2.1mm × 100mm |
MVX-0021A | TARQ-21SU | 22 in-lb | Yes |
| 2.1×150 (AX2115QZ) | RATH-2115 2.1mm × 150mm |
MVX-0021A | TARQ-21SU | 22 in-lb | Yes |
| 3.0×50 (AX3050QK) | CAEL-3050 3.0mm × 50mm |
MVX-0030A | TARQ-30SU | 35 in-lb 3.0mm kits | Yes |
| 3.0×100 (AX3010QK) | CAEL-3010 3.0mm × 100mm |
MVX-0030A | TARQ-30SU | 35 in-lb | Yes |
| 3.0×150 (AX3015QK) | CAEL-3015 3.0mm × 150mm |
MVX-0030A | TARQ-30SU | 35 in-lb | Yes |
All 6 kit variants use identical frit and fitting per group. Tube length/diameter only determines reference SKU.
Core Family Comparison Matrix
| Family | Material | Thread | Finish | Torque | Notes |
|---|---|---|---|---|---|
| SS Kits | Aurex 316 SS | ¼-28 UNF / 5⁄16-32 | 8/16/28 µin | 22/35 in-lb | Global, interchangeable Standard |
| Glass-Lined Kits | Glass-lined SS | Same | Same | Same | Thermal risk Handle carefully |
| PEEK Tube | Kynatec 450G/381G | 8-32 / 10-32 / 3⁄8-16 | 32 RMS | Hand | Material unique QC Critical |
| Gold Viper Fit. | 1.4404 SS + Au | UNF-mod 10-32 | Ra 0.8µm + Au | Hand | Do not touch after gold Special pkg |
| Ti Nuts/Fit. | Ti-Grade 5/2 | M10×0.8 | Optional Au | 120 cNm | No mixing by grade Strict |
Substitution across families—especially thread, torque, or material—remains principal field failure mode.
Meta/Analytical Highlights
- Full normalization: >1,700 line-items, consolidated into practical and audit-safe groupings.
- Standardization yields: Identifies that a single collared frit per diameter, a single end-fitting per thread, and three tube lengths cover nearly all stainless kits.
- Risk: Incorrect torque or mixing end-fittings remains dominant root-cause for downtimes/regulatory issues. Major Root Cause
- Recommendation: Robust labeling and assembly safeguards are required for glass, gold, and titanium variants.
Quick Wins
Immediate Action Items for BOM Governance
-
Standardize inventory on one frit PN per diameter and one end-fitting per thread group for stainless kits.
Drives cost and QA gains globally - Flag substitutions between families (e.g., SS vs. glass, PEEK, gold, titanium) at all kitting/assembly points; add QA controls for torque spec. Critical Control
- Enhance labeling and training at points of assembly, especially for specialty kits/fittings (glass, gold, titanium). Immediate Impact
- Request full detail on non-stainless kits from appendix (available on request) to audit for further harmonization opportunities.
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